临产孕妇凝血指标的检测与分析

目的通过对产前凝血功能的检测与分析，探讨正常妊娠临产孕妇组与有不良妊娠史（包括死胎、脊拄裂、脑积水、唇腭裂、肾积水等）临产孕妇组凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）、凝血酶时间（TT）、纤雏蛋白原（FIB）四项指标变化情况，为防止孕妇在分娩过程中出现产后大出血或血栓的形成提供科学的依据。方法采用Sysmex-50凝血分析仪对448例临产孕妇与50例健康非妊娠妇女为对照组的结果进行比较分析。结果正常妊娠史组与有不良妊娠史组临产孕妇的PT、TT明显低于对照组，有显著性差异（P〈0．01）；而FIB明显高于对照组，有显著性差异（P〈0．01）；册与对照组比较无明显差异（P〉0．05）。结论临产孕妇血液呈高凝状态，有利于产后快速有效的止血，临产前及时检测凝血四项指标对预防产科异常出血及并发症（如：DXC）有着极其重要的意义。

Detection and Analysis of Coagulation Indexes in Parturient Women

Objective To explore the changes of four blood coagulation indexes of normal pregnant women and the pregnant women with an adverse pregnancy history （including stillbirths, spins bifida, hydrocephalus, cleft lip and palate, hydronephrosis, etc. ） ,and provide scientific basis for preventing postpartum hemorrhage, or thrombosis. Methods To choose 448 cases of pregnant women （study group） and 50 cases of healthy nonpregnant women （control group）, then test the four blood coagulation indexes as PT,APTT,TT and FIB by Sysmex - 50 blood coagulation test machine. Results In normal pregnancy group and adverse pregnancy history group of pregnant women , the levels of PT, Tr was signiiicanfly lower than the control group, there were significant differences （P 〈 0.01） ; while the level of FIB was significantly higher, there were significant differences （ P 〈 0.01 ） ; the level of APTT compared with the control group, was no significant difference （ P 〉 0.05）. Conclusion The blood of parturient women is in hypercoagnlable state which can be beneficial for stopping bleeding postpartum. The detection of four blood coagulation indexes is important to diagnose DIC and prevent the abnormal bleeding.