Rapid dynamic CT scanning to distinguish schizophrenic from normal subjects |
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| Authors: | M Dysken C S Patlak G D Dobben K D Pettigrew J J Bartko E M Burns J Davis D A Regier |
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| Affiliation: | 1. Basque Center on Cognition, Brain and Language, San Sebastián, Spain;2. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;3. C.S. Kubik Laboratory for Neuropathology, Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;4. Department of Neurology, Boston University, School of Medicine, Boston, MA, USA;5. Department of Pathology, Boston University, School of Medicine, Boston, MA, USA;6. United States Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA, USA;7. Bedford Veterans Administration Medical Center, Bedford, MA, USA;8. Computer Science and AI lab, Massachusetts Institute of Technology, Cambridge, MA, USA;9. Department of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark;10. Department of Information and Computer Science, Aalto University, Finland;11. Department of Biomedical Engineering and Computational Science, Aalto University, Finland;1. Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, UK;2. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, USA;3. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, USA;4. Department of Radiology, Massachusetts General Hospital, Boston, USA;5. Neuroradiology Division, Massachusetts General Hospital, Boston, USA;6. Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, USA |
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| Abstract: | Rapid dynamic computerized axial tomography (CT) density-time curves were used to detect abnormal brain regions in groups of controls and DSM-III diagnosed schizophrenics. Density-time curves were designated as plateau curves if, following a bolus injection of contrast material, they exhibited a plateau from the peak value rather than a decrease. Five of the 10 schizophrenics versus none of the 11 controls were found to possess two or more plateau curves. The physiological basis for the plateau curves is not known, but an increase in blood-brain-barrier permeability could be involved. |
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