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Cancer-specific health-related quality of life in children with brain tumors |
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| Authors: | Iori Sato Akiko Higuchi Takaaki Yanagisawa Akitake Mukasa Kohmei Ida Yutaka Sawamura Kazuhiko Sugiyama Nobuhito Saito Toshihiro Kumabe Mizuhiko Terasaki Ryo Nishikawa Yasushi Ishida Kiyoko Kamibeppu |
| Affiliation: | 1. Department of Family Nursing, Faculty of Medicine, Graduate School of Health Sciences and Nursing, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan 2. Children’s Cancer Association of Japan, 1-3-12 Asakusabashi, Taito-ku, Tokyo, 111-0053, Japan 3. Division of Pediatric Neuro-Oncology, Department of Neuro-Oncology/Neurosurgery, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1298, Japan 4. Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan 5. Department of Pediatrics, Teikyo University Mizonokuchi Hospital, 3-8-3 Mizonokuchi, Takatsu-ku, Kawasaki-shi, Kanagawa, 213-8507, Japan 6. Sawamura Neurosurgery Clinic, North-7, West-5, Kita-ku, Sapporo, 060-0807, Japan 7. Department of Clinical Oncology & Neuro-oncology Program, Hiroshima University Hospital, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan 8. Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan 9. Department of Neurosurgery, Kurume University School of Medicine, Asahimachi 67, Kurume-shi, Fukuoka, 980-8574, Japan 10. Department of Neuro-Oncology/Neurosurgery, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1298, Japan 11. Center for Child Health, Ehime Prefectural Central Hospital, 83 Kasuga-machi, Matsuyama, Ehime, 790-0024, Japan |
| Abstract: | PurposeTo understand the influence of disease and treatment on the health-related quality of life (HRQOL) of children with brain tumors, compared to the HRQOL of children with other cancers, from the viewpoints of children and parents.MethodsA total of 133 children aged 5–18 years and 165 parents of children aged 2–18 completed questionnaires of the Pediatric Quality of Life Inventory Cancer Module (Pain and Hurt, Nausea, Procedural Anxiety, Treatment Anxiety, Worry, Cognitive Problems, Perceived Physical Appearance, and Communication scales); higher scores indicate a better HRQOL. The Cancer Module scores, weighted by age and treatment status, were compared to those obtained in a previous study of children with other cancers (mostly leukemia).ResultsThe weighted mean scores for Pain and Hurt (effect size d = 0.26) and Nausea (d = 0.23) from child reports and the scores for Nausea (d = 0.28) from parent reports were higher for children with brain tumors than scores for children with other cancers. The scores for Procedural Anxiety (d = ?0.22) and Treatment Anxiety (d = ?0.32) from parent reports were lower for parents of children with brain tumors than the scores for parents of children with other cancers. The child-reported Pain and Hurt score of the Cancer Module was higher (d = 0.29) and in less agreement (intraclass correlation coefficient = 0.43) with scores from the Brain Tumor Module, indicating that assessments completed with the Cancer Module misesteem pain and hurt problems in children with brain tumors.ConclusionsThe profiles of cancer-specific HRQOL in children with brain tumors differ from those of children with other cancers; we therefore suggest that these children receive specific psychological support. |
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