Development of amino acid conjugated sulfonamides as potent antiulcer agent |
| |
Authors: | Shakti Prasanna Sahoo Bharat Bhusan Subudhi |
| |
Affiliation: | 1. GIET School of Pharmacy, Chaitanya Knowledge City, Rajahmundry, 533296, Andhra Pradesh, India 2. School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, 751003, Orissa, India
|
| |
Abstract: | A series of 2-{[(4-methylphenyl) sulfonyl] amino}-3-sulfanylpropanoic acid (1a) and its analogs 1b–j have been synthesized. These compounds were screened for their in vivo efficacy in pyloric ligation model. Compounds 1a and 1b with higher antiulcer potential were further screened in other gastric models to explore the mode of antiulcer action. To further understand the mode of action, in vitro inhibition of H+/K+ ATPase activity in gastric microsome isolated from rat stomach was studied. This was rationalized by in silico experiments. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|