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Detection of antimicrofilarial ES antigen-antibody in immune complexes in Bancroftian filariasis by enzyme immunoassay |
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| Authors: | G B Prasad I Kharat B C Harinath |
| Affiliation: | Dept. of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India 442 102 |
| Abstract: | An enzyme immunoassay using penicillinase conjugated to Wuchereria bancrofti microfilarial ES antigen has been developed to detect specific antibody in circulating immune complexes in Bancroftian filariasis. Immune complexes were prepared by 3% polyethylene glycol (PEG) precipitation. 44 sera belonging to different groups were tested. 16 of 19 clinical filarial and two of 16 endemic normal sera but none of the non-endemic normal sera showed the presence of antimicrofilarial ES antigen-antibody in immune complexes. |
| Keywords: | Address for correspondence: Dr. B. C. Harinath Prof. & Head of the Dept. of Biochemistry M.G. Institute of Medical Sciences Sevagram Wardha (Dt) India -442 102. |
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