| 尼美舒利3种制剂的药代动力学研究 |
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| 引用本文： | 张先洲,马福旺,李荣凌.尼美舒利3种制剂的药代动力学研究[J].中国药师,1999,2(4):173-174. |
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| 作者姓名： | 张先洲 马福旺 李荣凌 |
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| 作者单位： | 湖北医科大学附一院药学部，湖北医科大学附一院药学部，湖北医科大学附一院药学部，湖北医科大学附一院药学部，湖北医科大学附一院药学部 武汉 430060，武汉 430060，武汉 430060，武汉 430060，武汉 430060 |
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| 摘 要： | 目的:测定尼美舒利在兔体内药物代谢动力学过程,比较片剂、混悬剂、栓剂的药动学参数。方法:用高效液相色谱法测定血浆中尼美舒利浓度,用3P87程序处理血药浓度数据。结果:片剂与混悬剂的药动学参数无显著性差异(P>0.05),栓剂的T_(max)、t1/2ke明显长于片剂和混悬剂,相对于片剂的生物利用度为79.9％,相对于混悬剂的生物利用度为74.5％。
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| 关 键 词： | 尼美舒利 片剂 混悬剂 栓剂 药代动力学 生物利用度 |
Study on Pharmacokinetics of Three Preparations from Nimesulide |
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| Zhang Xianzhou,Ma Fuwang,Li Rongling,Luo Shunde,Cai Hongsheng.Study on Pharmacokinetics of Three Preparations from Nimesulide[J].China Pharmacist,1999,2(4):173-174. |
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| Authors: | Zhang Xianzhou Ma Fuwang Li Rongling Luo Shunde Cai Hongsheng |
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| Institution: | Zhang Xianzhou,Ma Fuwang,Li Rongling,Luo Shunde,Cai Hongsheng Department of Pharmacy,The First Affiliated Hospital of Hubei Medical University,Wuhan 430060,P. R. China |
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| Abstract: | Objective: To study the pharmacokinetics properties and pharmacokinetic parameters of nimesulide in tablet, suspension, and suppository. Method: The plasma concentration of nimesulide was determined by HPLC. the data was treated with 3p87 procdeure. Result: There was a significant difference in the pharmacokinetics parameters between ninesulide tablet and nime-sulid suspension. tmax, t1/2ke of suppository were longer than that of tablet and suspension. The bioavailability of suppository to tablet was 79.9 % and to suspension 74.5 % . |
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| Keywords: | Nimesulide Tablet Suspension Suppository Pharmacokinetics Bioavailability |
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