Age-independent first trimester screening for Down syndrome: analysis of three modified software programs with 6,508 pregnancies |
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| Authors: | C. Hörmansdörfer M. Golatta A. Scharf P. Hillemanns P. Schmidt |
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| Affiliation: | (1) Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str.1, Hannover, 30625, Germany;(2) Department of Obstetrics and Gynaecology, Medical University of Heidelberg, Heidelberg, Germany |
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| Abstract: | Background The conventional first trimester screening (FTS) method integrates maternal age into risk calculation. It was suggested that this concept increases the false-positive rate in older, and the false-negative rate in younger mothers. |
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