Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis |
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| Authors: | Wormley F L Steele C Wozniak K Fujihashi K McGhee J R Fidel P L |
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| Affiliation: | Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. |
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| Abstract: | Conditions consistent with tolerance or immunoregulation have been observed in experimental Candida albicans vaginal infections. The present study investigated the role of gamma/delta T cells in experimental vaginal candidiasis. Results showed that T-cell receptor delta-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma/delta T cells in Candida vaginitis. |
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