早期药物联合治疗对急性脑梗死患者MMSE、ADL、SSS等指标的影响研究

目的 观察早期单唾液酸四己糖神经节苷脂(申捷)联合丹红注射液治疗急性脑梗死的临床疗效.方法 将120例急性脑梗死患者随机分为3组,每组各40例,3组患者均予常规对症治疗.观察组在常规治疗基础上加用申捷40 mg,静脉滴注,1次/d,共15 d;丹红注射液40 ml,静脉滴注,1次/d,共15 d.对照组A在常规治疗的基础上加用申捷40 mg,溶于0.9氯化钠注射液250 ml中静脉滴注,1次/d,15 d为1个疗程.对照组B在常规治疗基础上加用丹红注射液40 ml/次,静脉滴注,1次/d,共15 d.观察3组临床疗效及神经功能评分.结果 观察组有效率为75.0%,显著高于对照组A、B的50.0%,两组比较具有统计学意义(P<0.05).3组MMSE、ADL、SSS、HAMD评分与治疗前比较均好转(P<0.05),但观察组治疗效果显著优于单纯加用神经节苷脂或者丹红注射液治疗(P<0.05).结论 申捷联合丹红注射液治疗急性脑梗死临床疗效满意.

The influence of early drug combination treatment on patients with acute cerebral infarction about MMSE, ADL, SSS etc.

Objective To observe the clinical efficacy of early ganglioside （Shen Jie） joint with Dan- hong injection for acute cerebral infarction. Methods 120 cases of acute cerebral infarction were randomly di- vided into three groups, 40 cases in each group, all patients in the three groups were given traditional symptom- atic treatment. On the basis of conventional therapy, observation group were given Shen Jie, 40 mg, ivdrip, qd for 15 days and Danhong injection, 40 ml, ivdrip, qd for 15 d. Control group A were only given Shen Jie and control group B were only given Danhong injection. To observe the clinical efficacy and neurological score of the patiems in the three groups. Results The effective rate of the observation group was 75.0%, which was signif- icantly higher than 50. 0% in control group A and B, there was statistically significant （P 〈 0.05 ）. The MMSE, ADL, SSS, HAMD score of the three groups all improved after treatment （P 〈 0.05 ）. However, the therapeutic effect of the observation group was significantly better than that only using ganglioside or Danhong-injection treatment （ P 〈 0. 05 ）. Conclusion The clinical efficacy of Shen Jie joint with Danhong injection for acute cerebral infarction is satisfactory.