氟比洛芬酯对前列腺电切手术超前镇痛的临床研究

目的观察氟比洛芬酯对于前列腺电切手术(TURP)的超前镇痛作用。方法 60例前列腺增生(BPH)患者随机分成A、B、C三组,每组各20例,均在连续硬膜外麻醉下行经尿道前列腺电切术(TURP)。A组术前30min静注氟比洛芬醋50mg,术毕静注生理盐水10mL。B组于术前30min静注生理盐水10mL,术毕时静注氟比洛芬酯50mg。C组在手术前后均静注生理盐水10mL。术后用视觉模拟评分法(VAS)单盲评估患者术后1、2、6、12、24、48h疼痛感觉程度和与氟比洛芬酯有关的不良反应。结果 A组术后24hVAS评分显著低于C组(P<0.05),B组1h、2hVAS评分与C组无显著性差异(P>0.05),6、12、24h显著低于C组(均P<0.05),3组48hVAS评分无显著性差异(P>0.05)。结论氟比洛芬酯对TURP患者具有良好的超前镇痛作用,且无明显不良反应。

Clinical Research about Flurbiprofen Used for Preemptive Analgesiain Patients undergo TURP Surgery

Objective To assess the effects of preemptive analgesia with flurbiprofen on the postoperative pain for patients who were undergoing TURP surgery. Methods Sixty cases scheduled for selective TURP surgery were randomLy divided into A, B and C groups, they were all adopted by continuous epidural anesthesia. Thirty minutes before operation, the patients in group A received flurbiprofen 50mg intravenously.After operation, the patients in group B received flurbiprofen 50mg and group A, group C received normal saline 10mL.The effects of analgesia after operation were assessed by visual analogue scale （VAS） at1, 2, 6, 12, 24, 48hours after operation and side effects were also assessed. Results The VAS of group A was lower than that of group C during 24 hours after operation（P0.05）, The VAS were same between group B and group C at the time point of 1, 2 hour（P0.05）. The VAS of group B was lower than that of group C at the time point of 6, 12, 24 hour（P0.05）. The VAS were same in the three groups at the time point of 48 hour（P0.05）. Conclusion Preemptive analgesia with flurbiprofen 1mg/kg could provide satisfactory pain relief with no obvious side effects during 24 hours after TURP surgery.