Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression |
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Authors: | Querfeld C Sollberg S Huerkamp C Eckes B Krieg T |
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Affiliation: | Department of Dermatology, University of K?ln, Klinik und Poliklinik für Dermatologie und Venerologie, D-50924 K?ln, Germany. |
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Abstract: | Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis. Using in situ hybridization, marked expression of alpha1(I)-collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis. However, transforming growth factor (TGF)-beta1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF-beta1 mRNA could indicate that tumour-derived factors induce the expression of CTGF. |
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Keywords: | α1(I)-collagen connective tissue growth factor paraneoplasm pseudoscleroderma squamous cell carcinoma |
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