| 胍丁胺中枢作用的复杂性及多样性 |
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| 引用本文： | 翁谢川,郑建全,李锦,肖文彬.胍丁胺中枢作用的复杂性及多样性[J].中国药理学通报,2003,19(3):257-260. |
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| 作者姓名： | 翁谢川 郑建全 李锦 肖文彬 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 摘 要： | 1994年 ,人们发现胍丁胺在牛脑中具有可乐定替代物质的特性。随之的研究表明 ,胍丁胺的作用机制复杂 ,作用靶点多样 ,生物学效应广泛。最近的研究显示 ,胍丁胺是中枢的一种新的神经递质 ,胍丁胺可能是咪唑啉受体的内源性配体
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| 关 键 词： | 胍丁胺 神经递质 咪唑啉受体 配体 |
| 文章编号： | 1001-1978(2003)03-0257-04 |
| 修稿时间： | 2002年8月22日 |
Complicated and diverse effects of agmatine on central nervous system |
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| WENG Xie Chuan,ZHENG Jian Quan,LI Jin,XIAO Wen Bin.Complicated and diverse effects of agmatine on central nervous system[J].Chinese Pharmacological Bulletin,2003,19(3):257-260. |
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| Authors: | WENG Xie Chuan ZHENG Jian Quan LI Jin XIAO Wen Bin |
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| Abstract: | Agmatine was first identified and characterized as a candidate for CDS (clonidine displacing substance) in the bovine brain in 1994. The following researches demonstrated that agmatine was a widely distributed endogenous substance and performed a lot of biological functions in the central nervous system. The evidences revealed its targets were diverse and its mechanisms were complicated. Now it is well accepted that agmatine is a new neurotransmitter and/or neuromodulator and it might be an endogenous ligand of imidazoline receptor. |
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| Keywords: | agmatine neurotransmitter imidazoline receptor ligand |
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