免疫增强型肠内营养制剂对结直肠肿瘤术后机体免疫的影响

目的探讨免疫增强型肠内营养制剂对结直肠肿瘤患者术后的代谢及免疫功能的影响。方法选择结直肠肿瘤患者72例,术后分别接受免疫增强型肠内营养制剂(研究组,36例)或常规肠内营养制剂营养支持(对照组,36例),于术前、术后第1、8天分别检测患者的免疫系统、炎症反应及营养指标。结果术后第8天,研究组血清谷氨酰胺、精氨酸、外周血淋巴细胞总数、CD4+、自然杀伤细胞(NK)、免疫球蛋白(Ig)G、IgM明显高于对照组,白介素(IL)-6、肿瘤坏死因子(TNF)-α水平低于对照组,组间比较差异有统计学意义(P<0.05)。结论免疫增强型肠内营养制剂能改善结直肠肿瘤患者手术创伤后的细胞免疫和体液免疫功能。

Effect of immune-enhanced enteral diet on postoperative immunological function in patients with colorectal cancer

OBJECTIVE: To explore the influence of immune-enhanced enteral diet on postoperative metabolism and immunological function in colorectal tumor patient. METHODS: Seventy-two patients with colorectal cancer were enrolled in this study. Immune-enhanced enteral diet was administrated in 36 cases (study group), while regular enteral nutrition (EN) was given in 36 cases (control group). The immunological function, inflammatory function and nutrition index were evaluated before operation and on postoperative day 1 and day 8. RESULTS: Serum levels of glutamine, asparagines, CD4 (+), NK, IgG, IgM were higher in the study group than those in the control group. The levels of IL- 6, TNF-alpha in the study group were lower than those in the control group. The difference was statistically significant (P< 0.05). CONCLUSIONS: Immune-enhanced enteral diet can ameliorate the cell immunological and fluid immunological function in the patients with colorectal cancer after the procedures.