C反应蛋白含量测定在急性冠脉综合征中的临床意义

目的:探讨急性冠脉综合征(ACS)患者C反应蛋白(CRP)含量变化及其对预后的影响。方法:选择ACS患者共40例,其中不稳定心绞痛(UAP)组(B组)25例,急性心肌梗死(AMI)组(C组)15例,正常对照组(A组)20例作为研究对象,采用液相免疫沉淀散射比浊终点测定法检测60例入选对象的血清CRP浓度,并记录4周内所有患者的病情转归情况。结果:ACS两组中CRP水平均明显高于正常对照组(P<0.01),AMI组CRP水平高于UAP组(P<0.05);同时通过临床观察发现CRP水平相对高者病情转归及预后差,相对低者病情转归及预后良好。结论:CRP是ACS发生的一种危险因子,并且与病情的严重程度呈正相关,对病情转归的预测有一定价值。

Clinical significance of the changes of C-reactive protein level in patients with acute coronary syndrome

Objective:To discuss the content changes of C-reactive protein(CRP)and its influence to prognosis of the acute coronary syndrome(ACS).Methods:CRP level of 25 patients with unstable angina pectoris(group B)and 15 patients with acute myocardial infarction(group C)were measured,20 persons of normal health examination were selected as a control group(group A).Results:There was significant difference in the serum level of C-reactive protein between the ACS group and the control group(P<0.01).The serum level of CRP in the group with AMI was higher than that in the UAP group(P<0.05).Conclusion:CRP is a risk factor for ACS,and CRP has a positive association with ACS,and it is regarded as an indication for the prognosis of ACS.