心元胶囊对冠心病心率变异性的影响

目的观察心元胶囊治疗冠心病对心脏自主神经功能的影响。方法对照组94例，进行基础治疗；心元胶囊组94例，在基础治疗上加用心元胶囊3个月。所有患者治疗前后均进行24hHolter检查，对心元胶囊治疗前后及对照组进行心率功率谱时域和频域分析。结果心元胶囊组治疗后心率变异性（heart rate variability，HRV）值较对照组显著改善，其中时域指标：全部正常R—R间期的标准差（SDNN）、每5minR—R间期均值的标准差（SDANNI）、SDNN的均值（SDNNI）、正常相邻R—R间期差值的均方根（RMSSD）、正常相邻R-R间期差值〉50ms的百分比（PNN50）、心率均显著改善（P〈0．05）；频域指标：总频谱（TF）、低频（LF）和高频（HF）亦明显改善（P〈0．05）。结论心元胶囊可改善冠心病患者的HRV。

Effects of xinyuan capsule on heart rate variability in coronary heart disease

Objective To study the effect of xinyuan capsule on heart rate variability in coronary heart disease. Methods Forty nine patients treated by routine measure acted as controls. After treated by routine measure ,forty five patients were treated with I-zh-BNP for 24 hours. The heart rate power spectral density and time-domain were analyzed with 24 hour electrocardiographic recordings before and after using Lrh-BNP. Results Compared with the control group, time-domain analysis in Lrh-BNP after the treatment revealed a significant improved in SDNN,SDANNI,SDNNI, RMSSD, PNN50 （ P 〈 0.05）, heart rate and frequency domain analysis revealed a marked improved of total, low and high frequency components （ P 〈 0.05 ）. Conclusions Lrh-BNP can significantly improve the heart rate variability in ADHF.