| 非协调性异种肝移植动物模型的建立 |
| |
| 引用本文： | 孙鹏,蔡端,张群华,芮晓辉. 非协调性异种肝移植动物模型的建立[J]. 肝胆胰外科杂志, 2001, 13(1): 21-23. DOI: 10.11952/j.issn.1007-1954.2001.01.012 |
| |
| 作者姓名： | 孙鹏 蔡端 张群华 芮晓辉 |
| |
| 作者单位： | 上海市华山医院 普外科,上海 200040; |
| |
| 基金项目： | 上海市科委资助!项目 (98xD14 0 0 2 ) |
| |
| 摘 要： | 目的:建立豚鼠至大鼠异种肝移植的动物模型 。方法:利用血管套技术和显微外科技术进行了23例豚鼠至大鼠肝移植。观察存活时间、谷丙转氨酶（ALT）和移植肝病理变化、荧光染色 。结果:移植大鼠存活时间平均为135.10±46.12分钟,肝细胞发生弥漫性水样变性,IgG和IgM沉积于血管内皮细胞和肝血窦 。结论:豚鼠至大鼠异种移植模型存活时间有限,移植肝发生了超急性排斥反应。
|
| 关 键 词： | 肝移植 移植 异种 超急性排斥反应 动物实验替代试验 |
| 文章编号： | 1007-1954(2001)01-0021-03 |
| 收稿时间： | 2001-01-28 |
| 修稿时间： | 2001-01-28 |
Discordant xenotransplantation in guinea pig-to-rat |
| |
| SUN Peng,CAI Duan,ZHANG Qun hua,et al.. Discordant xenotransplantation in guinea pig-to-rat[J]. Journal of Hepatopancreatobiliary Surgery, 2001, 13(1): 21-23. DOI: 10.11952/j.issn.1007-1954.2001.01.012 |
| |
| Authors: | SUN Peng CAI Duan ZHANG Qun hua et al. |
| |
| Affiliation: | SUN Peng,CAI Duan,ZHANG Qun hua,et al. Department of General surgery,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040 |
| |
| Abstract: | Objective：To establish the model of discordant xenotransplantaion in guinea pig-to-rat.Methods：We did 23 cases of xenotransplantation by the cuff and microsurgical techniques for vessel anastomoses. The survival time, ALT and histology were examined.Results：The mean survial time of receptor rats were(135.10±46.12) minutes. Diffusely swelling liver cells were found. There were both IgG and IgM deposition on the endothelium and hepatic sinus.Conclusion：Hyperacute rejection was found in our model. |
| |
| Keywords: | liver transplantation transplantation heterologous hyperacute rejection animal testing alternatives |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《肝胆胰外科杂志》浏览原始摘要信息 |
|
点击此处可从《肝胆胰外科杂志》下载全文 |
