人与猪肝门静脉壁的细胞核密度的形态定量比较研究

目的比较研究人与猪肝门静脉细胞核密度间的异同,为猪与人异种肝移植提供理论依据。方法取人与不同月龄猪肝门静脉,常规有蜡包埋、切片,苏术精-伊红染色,桔黄G染平滑肌,光镜观察及计算机图像分析。结果猪肝静脉壁的细胞核数密度、面密度均随月龄的增加而降低。6月龄猪肝门静脉壁的细胞核数密度、面密度与人相近。结论猪肝门静脉壁的细胞核数密度、面密度随增龄发生变化,在行猪→人异种肝移植时,人与6月龄猪肝门静脉的吻合是可行的。

Morphometrical contrasting study on cellular nuclear density of the hepatic portal vein between the human and pig

Objective To study the cellular nuclear density difference of the hepatic portal vein between the human and pig and provide evidence for pig- to-human liver xenotransplantation. Methods The hepatic portal vein of human an d pig were collected and celluar density were measure with image analysis syste m at light microscopoic level. Results In the hepatic portal vein of pig, the cellular nuclear density decreased with aging changes, There was no difference b etween the 6 months old pigs and normal adult humans. Conclusion The cellular n uclear density of the hepatic portal vein of pig changes with age. the cellular nuclear density of 6 months pig was similar to human's. It is feasible to anasto mosis the hepatic portal vein of 6 months pig and human.