123例原发性IgA肾病患者临床特点与病理分析

目的：探讨原发性IgA肾病患者临床表现、病理特点及其相关性。方法：回顾性总结分析123例经肾活检病理确诊为原发性IgA肾病的临床和病理资料。结果：123例IgA肾病患者在21岁～40岁年龄段发病率最高（占65.8%）;临床表现以发作性肉眼血尿最多见（占36.6%）;病理类型分级以Ⅱ级（56.1%）,Ⅲ级（20.3%）为主;病理类型与临床表现呈正相关（P〈0.01）;随着Lee氏病理分级程度的增高,血肌酐、血尿酸、血脂有不同程度的升高（P〈0.05）。结论：IgA肾病临床类型多样,其组织形态学改变轻重不一,宜尽早做肾活检以明确诊断,指导治疗。

Clinical Features and Pathological Analysis of 123 Patients with Primary IgA Nephropathy

Objective：To study the relationship between clinical manifestation and pathological feature with primary IgA nephropathy.Methods：The clinical and pathological data of 123 patients with primary IgA nephropathy diagnosed by renal biopsy were retrospectively analyzed.Results：The incidence of 123 IgA nephropathy was the highest in patients at the age of 21～40 years （65.8%）.Clinically,IgA nephropathy of the paroxysmal gross hematuria type was the most common among the patients（36.6%）.The pathological type Ⅱ was the most common （56.1%） followed by type Ⅲ（20.3%）.Pathological type was positively correlated with the clinical manifestations（P0.01）.Serum creatinine,serum uric acid and blood lipid levels increased with Lee’s pathological grade increasing （P0.05）.Conclusion：IgA nephropathy had diverse clinical manifestations.Histomorphology changed with different severity.Early renal biopsy should be performed and appropriate therapy administered.