Movement disorders in childhood: classification and genetic update] |
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Authors: | A Roubertie F Rivier S Tuffery-Giraud V Humbertclaude M Claustres R Cheminal B Echenne |
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Institution: | Service de neuropédiatrie, h?pital Saint-Eloi, 80, avenue Augustin-Fliche, 34295 cedex 5 Montpellier, France. a_roubertie@hotmail.com |
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Abstract: | Abnormal movements are not unusual in childhood. Recent genetic progresses provide a new approach of childhood movement disorders. Several loci have been identified in paroxysmal dyskinesia, or in Gilles de la Tourette syndrome. A gene has been cloned in Hallervorden-Spatz syndrome, and a gene has recently been implicated in benign hereditary chorea. Considerable advances concern the genetic of dystonic syndromes: several chromosomal localizations have been identified, and several genes have been cloned. Genetic advances allow nosographic reclassification of some entities and offer new molecular tools for a more appropriate diagnosis. The increasing wealth of genetic knowledge will provide further insight in the understanding of abnormal movement disorders in childhood. |
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