Age-dependent changes in dopaminergic projections from the substantia nigra pars compacta to the neostriatum |
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Authors: | Ishida Yoshiyuki Okawa Yayoi Ito Sachiko Shirokawa Tetsuya Isobe Ken-Ichi |
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Affiliation: | Radioisotope Research Center, Nagoya University Graduate School of Medicine, Japan. ishida@med.nagoya-u.ac.jp |
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Abstract: | Age-dependent changes in dopaminergic (DA) innervation of the neostriatum (Str) were studied in male F344/N rats. Projections from the substantia nigra pars compacta (SNc) to the neostriatum were quantified using electrophysiological methods at age points from 6 to 24 months. The percentage of DA neurons activated antidromically by electrical stimulation (P-index) of Str increased between 18 and 24 months. Additionally, the percentage of DA neurons showing multiple antidromic latencies from striatal stimulation (M-index), which suggests axonal branching of individual DA neurons, increased significantly between 6 and 12 months and 6 and 24 months. These results suggest that DA neurons exhibit increased axonal branching in the aged brain. |
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Keywords: | Aging Substantia nigra pars compacta Electrophysiology F344 rat |
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