单纯肥胖对男性青少年性发育的影响

目的 :探讨单纯肥胖对男性青少年性发育的影响。方法 :测量 5 8例单纯肥胖青少年 (肥胖组 )和 4 6例同年龄、同身高体重正常者 (对照组 )的体重指数 (BMI)、臀围比值 (WHR)、阴毛发育程度、首次遗精发生率、阴茎大小、睾丸体积 ,放免法测定血清黄体生成素 (LH)、卵泡刺激素 (FSH)、总睾酮 (TT)、雌二醇 (E2 )、催乳素 (PRL)和空腹胰岛素 (INS)水平。结果 :肥胖组的阴毛发育程度、首次遗精发生率、阴茎和睾丸大小均明显小于对照组 ;而血清LH、FSH、PRL、INS均明显高于对照组 ,TT水平明显低于对照组 ,E2 水平 2组差异无统计学意义。肥胖组BMI与阴毛发育程度、阴茎长度、睾丸大小、血清TT水平呈显著负相关 ,r分别为 - 0 .2 91 ,- 0 .30 2 ,- 0 .31 7,- 0 .31 9,P均 <0 .0 5。BMI及WHR均与空腹INS水平呈正相关 ,r分别为 0 .30 1 ,0 .35 7,P均 <0 .0 5。结论 :肥胖引起男性青少年性发育滞后。

Effect of obesity on sexual development in male adolescents

Aim: To investigate the effect of obesity on sexual development in male adolescents. Methods: Both 58 simple obese male adolescents and 46 normal-weight controls were subjected to exam the natural lengths of penis, mean volume of testes (MTV), the first time of spermatorrhea, pubic hair stage. The levels of luteinizint hormone ( LH ), follicle-stimulating hormone ( FSH ), total testosterone ( TT), estradiol (E 2), PRL and fasting insulin concentrations in serum were detected by RIA. Results: Compared with controls, obese male adolescents presented significantly lower levels of TT and significantly higher levels of LH, FSH, PRL, and fasting insulin. The natural lengths of penis, MTV, the first time of spermatorrhea, and pubic hair stage were less in obese male adolescents than those in controls. Significant negative correlation was found between BMI and the natural lengths of penis, MTV, pubic hair stage, and serum TT levels in obese male adolescents, r was -0.302,-0.317,-0.291,-0.319, respectively ( P <0.05).Significant positive correlation was found between BMI, WHR and the fasting insulin concentrations ( r was 0.301 and 0.357, respectively, P <0.05). Conclusion: Sexual development is retarded in obese male adolescents.