| 酶法制备阿莫西林的工艺优化研究 |
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| 引用本文： | 朱科,王艳艳,丁海平,延国东,王峰. 酶法制备阿莫西林的工艺优化研究[J]. 中国抗生素杂志, 2011, 36(1) |
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| 作者姓名： | 朱科 王艳艳 丁海平 延国东 王峰 |
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| 作者单位： | 石药集团河北中润制药有限公司,石家庄,050041 |
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| 摘 要： | 目的 酶法合成阿莫西林工艺优化和稳定性研究.方法 利用对羟基苯甘氨酸甲酯为侧链在青霉素酰化酶催化下,与底物6-氨基青霉烷酸(6-APA)合成阿莫西林;对温度、pH、侧链与底物投料比、投酶量等条件进行优化;取化学法和酶法阿莫西林进行6个月加速实验,对比含量变化,考察成品稳定性.结果 工艺优化后阿莫西林摩尔收率达84.3%;6个月加速实验后酶法阿莫西林含量平均下降值比化学法少0.78%.结论 酶法阿莫西林工艺流程简单,方法绿色环保,杂质少,产品稳定性优于化学法.
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| 关 键 词： | 阿莫西林 青霉素G酰化酶 稳定性 |
Study on preparation of amoxicillin by enzymatic method |
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| Zhu Ke,Wang Yan-yan,Ding Hai-ping,Yan Guo-dong,Wang Feng. Study on preparation of amoxicillin by enzymatic method[J]. Chinese Journal of Antibiotics, 2011, 36(1) |
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| Authors: | Zhu Ke Wang Yan-yan Ding Hai-ping Yan Guo-dong Wang Feng |
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| Affiliation: | Zhu Ke,Wang Yan-yan,Ding Hai-ping,Yan Guo-dong and Wang Feng(Shijiazhuang Pharmaceutical Group Hebei Zhongrun Pharmaceutical Co.,LTD,Shijiazhuang 050041) |
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| Abstract: | Objective To study the process optimization and stability of amoxicillin by enzymatic synthesis.Methods The amoxicillin was synthesized with the use of p-hydroxyphenylglycine methyl ester as a side chain and the substrate 6-APA in penicillin acylase catalyzed;temperature,pH,side chain and substrate feed ratio,investment conditions,such as the amount of enzyme was optimized;chemical and enzymatic amoxicillin was taken six months accelerated test,comparing content changes,examining the stability of products.R... |
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| Keywords: | Amoxicillin Penicillin G acylase Stability |
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