| 多发性硬化人类白细胞抗原易感基因研究进展 |
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| 引用本文： | 邱伟,胡学强. 多发性硬化人类白细胞抗原易感基因研究进展[J]. 中国现代神经疾病杂志, 2012, 12(2): 127-130 |
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| 作者姓名： | 邱伟 胡学强 |
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| 作者单位： | 中山大学附属第三医院神经病学科多发性硬化临床研究中心,广州,510630 |
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| 基金项目： | 国家自然科学基金青年科学基金资助项目,广东省科技计划资助项目,广东省卫生厅基金 |
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| 摘 要： | 多发性硬化为一种免疫相关性中枢神经系统脱髓鞘疾病,临床表现呈异质性,好发于青壮年女性,病残率高,给患者家庭及社会造成沉重负担.遗传因素和环境因素共同参与其发病机制,而HLA基因复合体为重要的遗传学决定因素,占易感风险的60%,对其研究是目前多发性硬化遗传学研究的热点和难点.
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| 关 键 词： | 多发性硬化 HLA抗原 遗传学 综述 |
Human leukocyte antigen susceptibility genes in multiple sclerosis |
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| QIU Wei , HU Xue-qiang. Human leukocyte antigen susceptibility genes in multiple sclerosis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2012, 12(2): 127-130 |
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| Authors: | QIU Wei HU Xue-qiang |
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| Affiliation: | Multiple Sclerosis Clinical Research Center, Department of Neurology, the Third Affiliated Hospital of Sun Yatsen University, Guangzhou 510630, Guangdong, China |
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| Abstract: | Multiple sclerosis (MS) is an immune related demyelinating disease of the central nervous system. The onset age of MS is usually between 20-40 years, showing a heterogeneous clinical feature. Due to the high disability rate, MS causes a huge burden to the society. MS is a complex disease caused by the genetic and environmental factors, in which genetic factors play a critical role. HLA gene complex is the most important determinant in MS risk, with a risk factor rate more than 60% . HLA gene complex has been a focus in MS research worldwide. |
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| Keywords: | Multiple sclerosis HLA antigens Genetics Review |
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