| 毛叶假鹰爪素C衍生物的合成与抗肿瘤活性评价 |
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| 引用本文： | 舒彦松,张学辉,向卓,梁海,吴久鸿. 毛叶假鹰爪素C衍生物的合成与抗肿瘤活性评价[J]. 解放军药学学报, 2013, 0(5): 403-406 |
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| 作者姓名： | 舒彦松 张学辉 向卓 梁海 吴久鸿 |
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| 作者单位： | [1]安徽医科大学研究生学院,安徽合肥231032 [2]解放军306医院药学部,北京100101 [3]第四军医大学药学院,陕西西安710032 |
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| 基金项目： | 国家自然科学基金,No.30572212;81072546 |
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| 摘 要： | 目的设计并合成出一系列Desmosdumotin C衍生物并考察其抗肿瘤活性。方法以2,4,6-三羟基苯乙酮为 原料合成一系列Desmosdumotin C衍生物，目标化合物经过1H-NMR、MS鉴定。采用SRB法对其抗肿瘤活性进行初步评价。结 果与结论设计并合成了 19个新化合物,初步的细胞活性实验表明,该系列衍生物大多具有肿瘤增殖抑制活性,且与先导物相 当，其中3个化合物显示出良好的抗肿瘤活性，为进一步对先导化合物Desmosdumotin C衍生物的结构优化奠定了一定的基础。
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| 关 键 词： | Desmosdumotin C衍生物 合成 抗肿瘤活性 |
Synthesis and Antitumor Activity Evalution of Desmosdumotin C Derivatives |
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| SHU Yan-song,ZHANG Xue-hui,XIANG Zhuo,LIANG Hai,WU Jiu-hong. Synthesis and Antitumor Activity Evalution of Desmosdumotin C Derivatives[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2013, 0(5): 403-406 |
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| Authors: | SHU Yan-song ZHANG Xue-hui XIANG Zhuo LIANG Hai WU Jiu-hong |
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| Affiliation: | ①Graduate School,Anhui Medical University,Hefei 230032,China;②Department of Pharmacy,Hospital 306 of PLA, Beijing 100101,China;③School of Pharmacy,the Fourth Military Medical University ,Xi^n 710032,China |
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| Abstract: | Objective To design and synthesize a series of Desmosdumotin C derivatives and screen their anti-tumor activity. Methods These compounds were prepared from 2,4, 6-trihydroxyacetophenone as starting agents. Their structures were indetified by 1H-NMR and MS. The anti-tumor activity of the compounds was screened by SRB methods. Results and Conclusion Nineteen novel compounds have been synthesized,three of which have better anti-tumor activities. |
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| Keywords: | Desmosdumotin C derivatives ； synthesis ； antitumor activity |
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