| 四甲基吡嗪的溴代合成产物的GC/MS分析 |
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| 引用本文： | 陈晓颖,孙秀燕,钟大放,桑迎霞. 四甲基吡嗪的溴代合成产物的GC/MS分析[J]. 沈阳药科大学学报, 2001, 18(3): 192-194 |
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| 作者姓名： | 陈晓颖 孙秀燕 钟大放 桑迎霞 |
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| 作者单位： | 1. 沈阳药科大学分析测试中心,
2. 沈阳华泰药物研究所, |
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| 摘 要： | 采用气相色谱 质谱联用技术 ,对四甲基吡嗪的溴代合成产物进行分析。结果表明 ,目标化合物——— 2 溴甲基 3 ,5 ,6 三甲基吡嗪约占合成产物的 5 0 % ,尚有二溴、三溴取代物。本文得出可能的裂解途径 ,并对其中的主要成分进行结构鉴定。结果证明该方法可用于定性、定量地监测化学反应过程
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| 关 键 词： | 气相色谱质谱联用 四甲基吡嗪 溴代四甲基吡嗪 |
| 文章编号： | 1006-2858(2001)03-0192-03 |
| 修稿时间： | 2000-11-13 |
GC/MS analysis of the synthetic products of brominated tetramethylpyrazine |
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| CHEN Xiao-ying,SUN Xiu-yan,ZHONG Da-fang,SANG Ying-xia. GC/MS analysis of the synthetic products of brominated tetramethylpyrazine[J]. Journal of Shenyang Pharmaceutical University, 2001, 18(3): 192-194 |
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| Authors: | CHEN Xiao-ying SUN Xiu-yan ZHONG Da-fang SANG Ying-xia |
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| Affiliation: | CHEN Xiao ying 1,SUN Xiu yan 1,ZHONG Da fang 1,SANG Ying xia 2 |
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| Abstract: | A mixture of synthetic products of brominated tetramethylpyrazine was analyzed by the gas chromatography mass spectrometry. The possible fragmentation pathway of 2 bromomethyl 3,5,6 trimethylpyrazine, which was used to identify the structures of principal compounds, was revealed. The results showed that there were dibromo and tribromo substituted tetramethylpyrazines in the synthetic products except for the target compound 2 bromomethyl 3,5,6 trimethylpyrazine. Combination of GC and MS could be used in qualitatively and quantitatively monitoring of the synthetic processing. |
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| Keywords: | GC/MS tetramethylpyrazine 2-bromomethyl-3,5,6-trimethylpyrazine |
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