脑卒中患者B族Ⅰ型清道夫受体基因G4A多态性与血脂水平的关系

目的探讨B族Ⅰ型清道夫受体基因G4A多态性与脑卒中患者血脂水平的关系。方法采用聚合酶链反应限制片长多态性技术检测149例动脉粥样硬化性脑梗死患者、141例脑出血患者和120例健康对照者B族Ⅰ型清道夫受体基因G4A多态的分布,并测定三组研究对象的血脂水平。结果动脉粥样硬化性脑梗死组和脑出血组B族Ⅰ型清道夫受体G4A GA AA基因型亚组高密度脂蛋白胆固醇水平显著高于同组GG基因型亚组(P<0.05),低密度脂蛋白胆固醇水平显著低于同组GG基因型亚组(P<0.05)。对照组B族Ⅰ型清道夫受体G4A GA AA基因型亚组高密度脂蛋白胆固醇水平显著高于GG基因型亚组,而低密度脂蛋白胆固醇和总胆固醇水平显著低于同组GG基因型亚组(P<0.05)。男性动脉粥样硬化性脑梗死组和男性脑出血组GA AA基因型亚组高密度脂蛋白胆固醇水平显著高于同组GG基因型亚组,低密度脂蛋白胆固醇水平显著低于同组GG基因型亚组。女性动脉粥样硬化性脑梗死组和女性脑出血组不同基因型亚组体质指数和血脂水平差异无显著性。结论B族Ⅰ型清道夫受体基因G4A位点A等位基因可能与男性高密度脂蛋白和低密脂蛋白代谢有关。

The Relationship of Scavenger Receptor Class B Type I G4A Polymorphism and Serum Lipid Level in Stroke

Aim To study the effect of G4A polymorphism on serum lipid level of Han population in Hunan province. Methods G4A Polymorphisms of the scavenger receptor class B type I (SR-BI) gene were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) in atherosclerotic cerebral infarction (ACI) patients, cerebral hemorrhage (CH) patients and healthy controls. Results The serum level of high density lipoprotein cholesterol (HDLC) in SR-BI G4A GA AA genotype subgroup was markedly higher than that in GG genotype subgroup of the same group in ACI group (P<0.05), and it was the same with CH group. The serum level of low density lipoprotein cholesterol (LDLC) in SR-BI G4A GA AA genotype subgroup was evidently lower than that in GG genotype subgroup of the same group in ACI group (P<0.05), and it was the same with CH group. The serum level of HDLC in SR-BI G4A GA AA genotype subgroup was obviously higher than that in GG genotype subgroup of the same group in control group (P<0.05). The serum levels of LDLC and total cholesterol (TC) in SR-BI G4A GA AA genotype subgroup was significantly higher than those in GG genotype subgroup of the same group in control group (P<0.05). The serum level of HDLC in male ACI group and GA AA genotype subgroup of CH group was markedly higher while LDLC was markedly lower than that in GG genotype subgroup of the same group. There was no significant difference of body mass indexes and serum level in different genotype subgroups of female ACI group and CH group. Conclusions A allele of SR-BI G4A is possibly associated with the metabolism of HDL and LDL.