炔雌醇环丙孕酮联合二甲双胍治疗多囊卵巢综合征52例临床观察

目的：观察炔雌醇环丙孕酮（达英-35）联合二甲双胍治疗多囊卵巢综合征的临床效果。方法：52例多囊卵巢综合征患者按照入院顺序分为观察组和对照组,每组26例。观察组采用达英-35联合二甲双胍治疗,对照组采用达英-35治疗,比较两组的疗效。结果：两组治疗后黄体生成激素（LH）、睾酮（T）性激素水平均较治疗前改善明显,观察组治疗后LH、T水平较对照组明显降低,差异有统计学意义（P〈0.05）。观察组空腹血糖（FBG）水平治疗后与其治疗前及对照组比较,差异均有统计学意义（P〈0.05）。结论：达英-35联合二甲双胍治疗PCOS临床效果优于单用达英-35,临床疗效确切,且服用方便。

Clinical Research into the Treatment with Ethinylestradiol and Cyproterone Acetate Combined with Metformin in 52 patients with polycystic Ovary Syndrome

Objective： To explore the clinical efficacy of ethinylestradiol and cyproterone acetate（ Diane- 35） combined with meformin in the treatment of the patients with polycystic ovary syndrome（ PCOS）. Methods： Fifty-two patients with PCOS were divided into control group and observation group by hospitalizing order with 26 cases each. Patients in the observation group were given Diane-35 combined with metformin while patients in the control group were given Diane-35 only in their treatment. And then the curative effects of the two groups were compared. Results： After treatment,the hirsutism of the two groups was obviously reduced,and the acne was improved to different degrees; the luteinizing hormone（ LH） and testosterone（ T） sex hormone levels in both of the two groups were obviously improved; the LH of the observation group was significantly lowered than the control group; the T level of the observation group was lower than that of the control group. There was statistical difference in the comparison between the two groups（ P 0. 05）. After treatment,when the fasting blood-glucose（ FBG） level of the observation group was compared with that of the control group and before treatment,there was statistical difference in all the comparison（ P 0. 05）. Conclusion： The clinical effect of Diane-35 combined with metformin in patients with PCOS is better than Diane-35 only. The definite clinic effect and easy taking make it worthy of clinical diffusion and application.