| 云南赤芍抗乙型肝炎病毒的体外实验研究 |
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| 引用本文： | 肖会泉,刘安平,罗日永.云南赤芍抗乙型肝炎病毒的体外实验研究[J].中国中西医结合消化杂志,2004,12(2):93-94. |
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| 作者姓名： | 肖会泉 刘安平 罗日永 |
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| 作者单位： | 广州中医药大学附属第一医院内科,广州,510405 |
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| 摘 要： | 目的:初步研究云南赤芍的抗乙型肝炎病毒(HBV)作用。方法:通过云南赤芍作用于体外培养的2.2.15细胞,观察其对2.2.15细胞两抗原分泌的影响.初步评价其抗HBV作用。结果:云南赤芍作用于2.2.15细胞12d后,药物对2.2.15细胞的半数毒性浓度为3.85g／L,对HBsAg、HBeAg的半数抑制浓度分别为<0.156g／L、0.54g／L,治疗指数分别为>24.68、7.13。结论:云南赤芍在体外细胞培养中对两抗原的分泌有较好的抑制作用。
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| 关 键 词： | 云南赤芍 乙型肝炎病毒 体外实验 中医药疗法 抗原 细胞毒性 |
Experimental Study of Anti-HBV Effects of Radix Paeoniae Rubra in Yunnan in vitro |
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| AO Huiquan,LIU Anping,LUO Riyong.Experimental Study of Anti-HBV Effects of Radix Paeoniae Rubra in Yunnan in vitro[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2004,12(2):93-94. |
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| Authors: | AO Huiquan LIU Anping LUO Riyong |
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| Institution: | AO Huiquan,LIU Anping,LUO Riyong
Department of Internal Medicine,First Affiliated Hospital of Guangzhou University of TCM,Guangzhou 510405 |
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| Abstract: | jective:To explore anti-HBV effects of Radix Paeoniae Rubra in Yunnan (RPRY). Methods: 2. 2. 15 cell line was taken as cell model. The influence of RPRY on the secretion of the two antigens of 2. 2. 15 cells was observed. Results:Twelve days after the action of RPRY on the cells, its LD50 was 3. 85 g/L;ID50 to the HBsAg and HBeAg was lower than 0. 156 g/L and 0. 54 g/L respectively, Treatment index was higher than 24. 68 and 7. 13 respectively. Conclusion:RPRY can markedly inhibit the secretion of the two antigens in 2. 2. 15 cell line. |
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| Keywords: | patitis virus type B Radix Paeoniae Rubra |
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