Whole‐body magnetic resonance imaging evaluation of facioscapulohumeral muscular dystrophy |
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| Authors: | Doris G Leung MD John A Carrino MD MPH Kathryn R Wagner MD PhD Michael A Jacobs PhD |
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| Institution: | 1. Center for Genetic Muscle Disorders, The Hugo W. Moser Research Institute, Kennedy Krieger Institute, Baltimore, Maryland, USA;2. Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;3. Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;4. Department of Radiology and Imaging, Hospital for Special Surgery, New York, New York, USA;5. Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;6. Sidney Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA |
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| Abstract: | Introduction: Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. Increasing knowledge of the pathophysiology of FSHD has stimulated interest in developing biomarkers of disease severity. Methods: Two groups of MRI scans were analyzed: whole‐body scans from 13 subjects with FSHD; and upper and lower extremity scans from 34 subjects with FSHD who participated in the MYO‐029 clinical trial. Muscles were scored for fat infiltration and edema‐like changes. Fat infiltration scores were compared with muscle strength and function. Results: The analysis revealed a distinctive pattern of both frequent muscle involvement and frequent sparing in FSHD. Averaged fat infiltration scores for muscle groups in the legs correlated with quantitative muscle strength and 10‐meter walk times. Conclusions: Advances in MRI technology allow for acquisition of rapid, high‐quality, whole‐body imaging in diffuse muscle disease. This technique offers a promising disease biomarker in FSHD and other muscle diseases. Muscle Nerve 52: 512–520, 2015 |
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| Keywords: | facioscapulohumeral muscular dystrophy FSHD MRI radiographic biomarkers whole‐body imaging |
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