Assessment OF aged mdx mice by electrical impedance myography and magnetic resonance imaging |
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| Authors: | Jim S Wu MD Jia Li PhD Robert L Greenman PhD David Bennett PhD Tom Geisbush BA Seward B Rutkove MD |
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| Institution: | 1. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA;2. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA;3. Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA |
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| Abstract: | Introduction: Similar to magnetic resonance imaging (MRI), electrical impedance myography (EIM) is dependent on the presence and location of water in muscle to assess neuromuscular diseases. We compared the 2 technologies in mdx mice to better understand their relationship. Methods: EIM and MRI, using T2 relaxation and diffusion‐weighted imaging (DWI), were performed on the gastrocnemius of 10 mdx and 10 wild‐type mice. Muscle function and tissue composition measurements were compared with the EIM and MRI data. Results: EIM reactance and T2 relaxation mapping can discriminate healthy from diseased mice (P < 0.001 for both), but DWI could not. Both T2 relaxation and EIM reactance also correlated closely with muscle function/composition and with each other. Conclusion: Given the low cost of EIM and the simplicity of application, it may be a valuable alternative to muscle MRI in Duchenne muscular dystrophy, where simple cumulative indices of muscle health are being sought. Muscle Nerve 52: 598–604, 2015 |
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| Keywords: | Duchenne muscular dystrophy EIM impedance mdx mice MRI nerve conduction |
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