Resistance strength training exercise in children with spinal muscular atrophy |
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| Authors: | Aga Lewelt MD MS Kristin J. Krosschell PT DPT Gregory J. Stoddard MS Cindy Weng MS Mei Xue MS Robin L. Marcus PT PhD Eduard Gappmaier PT PhD Louis Viollet MD PhD Barbara A. Johnson PT PhD Andrea T. White PhD Donata Viazzo‐Trussell PT DPT Philippe Lopes PhD Robert H. Lane MD John C. Carey MD MPH Kathryn J. Swoboda MD |
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| Affiliation: | 1. Division of Physical Medicine and Rehabilitation, Pediatric Motor Disorders Research Program, University of Utah School of Medicine, Salt Lake City, Utah, USA;2. Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;3. Study Design and Biostatistics Center, University of Utah, Salt Lake City, Utah, USA;4. Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA;5. Department of Physical Therapy, University of Utah, Salt Lake City, Utah, USA;6. Department of Neurology, Pediatric Motor Disorders Research Program, University of Utah School of Medicine, Salt Lake City, Utah, USA;7. Department of Exercise and Sport Science, University of Utah, College of Health, Salt Lake City, Utah, USA;8. Neuromuscular Degeneration and Plasticity Laboratory, Institut National de la Santé et de la Recherche Médicale UMR‐S 1124, University Paris Descartes, Paris, France;9. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA;10. Division of Pediatric Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA |
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| Abstract: | Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home‐based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain‐free (99.8%), and no study‐related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12‐week supervised, home‐based, 3‐day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA. Muscle Nerve 52 : 559–567, 2015 |
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| Keywords: | home‐based exercise program neuromuscular disorder progressive resistance training exercise spinal muscular atrophy strength training exercise |
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