Genitourinary health in a population‐based cohort of males with Duchenne and Becker Muscular dystrophies |
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| Authors: | Yong Zhu PhD Paul A. Romitti PhD Kristin M. Caspers Conway PhD Sunkyung Kim PhD Ying Zhang PhD Michele Yang MD Katherine D. Mathews MD the Muscular Dystrophy Surveillance Tracking Research Network |
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| Affiliation: | 1. Department of Epidemiology, The University of Iowa, Iowa City, Iowa, USA;2. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA;3. Department of Biostatistics, Indiana University, Indianapolis, Indiana, USA;4. Department of Pediatrics, Children's Hospital Colorado, Aurora, Colorado, USA;5. Department of Pediatrics, The University of Iowa, Iowa City, Iowa, USA |
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| Abstract: | Introduction: Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population‐based data. Methods: Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU‐related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early‐ vs. late‐onset, ambulation status, scoliosis), and treatments (respiratory support, steroids). Results: Among the 918 males, 81 (9%) had a GU condition, with voiding dysfunction (n = 40), GU tract infection (n = 19), and kidney/ureter calculus (n = 9) most frequently seen. The Kaplan‐Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non‐ambulatory (HR 2.7, 95% CI 1.3–5.6). Conclusions: Our findings highlight the need for increased awareness of GU health and multidisciplinary care of DBMD patients. Muscle Nerve 52 : 22–27, 2015 |
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| Keywords: | Becker muscular dystrophy Duchenne muscular dystrophy epidemiology male urogenital diseases neuromuscular diseases |
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