肝炎患者念珠菌感染特点及药敏分析

目的分析肝炎患者念珠菌感染及药物敏感情况。指导临床合理治疗。方法通过APIATB系统和ATBFUNGUS试剂盒，对326株真菌培养阳性标本进行鉴定并对感染的念珠菌进行药敏测定与分析。结果在326株真菌标本中，念珠菌感染率最高占78．8％，其中白念珠菌感染占念珠菌的75％。标本以痰的检出率最高，在各类念珠菌感染标本中占55％；抗真菌药物5-氟胞嘧啶、两性霉素B、制霉菌素、眯康唑、益康唑和酮康唑对念珠菌的敏感率分别为95％、96％、96％、76％、51％和43％。结论肝炎患者真菌感染以念珠菌占首位，真菌感染部位以呼吸道为主。临床用药应根据念珠菌的药物敏感试验结果，综合分析，正确应用。

The feature of Candida infections of the patients with hepatitis and their drug susceptibility analysis

Objective To investigate Candida infections of the patients with infected hepatitis virus and drug susceptibility in the 302^th hospital of PLA for the guidance of rational use of antibiotics. Methods 326 fungus samples from the patients with hepatitis virus infection were determined by methods of API ATB system, part of their drug susceptibility were test with ATB FUNGUSR kit. Results The results showed that 22 species had been identified, and Candida was 78.8% in all fungi and Candida albicans is 75% of candidaial infections. The highest positive rate of samples was from sputum which was 55%. The sensitivity of Candida to 5-fluorocytosine, amphotericine B, nystatine, mieonazole, econazole and ketoconazole was 95%, 96%, 96%, 76%, 51% and 43% respectively. Conclusions The feature of Candida of the patients with hepatitis were the highest positive rate of fungal infections. We should pay more attentions to the treatment for the candidial infections and select antibiotic according to their drug susceptibility.