Spontaneous splenic rupture in atypical (Philadelphia chromosome negative) chronic myeloid leukaemia following blastic crisis |
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Authors: | Sachithanandan A Gleadhill I Alexander H D Morris T C M |
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Institution: | Department of Cardiac Surgery, Royal Victoria Hospital, Belfast BT12 6BA. anandsachithanandan@yahoo.com |
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Abstract: | Philadelphia chromosome negative and bcr/abl negative chronic myeloid leukaemia (CML) is an uncommon atypical CML. We describe a patient with this disorder who experienced an acute blastic transformation that resulted in rapid splenic enlargement and subsequent atraumatic splenic rupture. Clinically, spontaneous splenic rupture may be a difficult diagnosis to make and this case highlights the importance of considering atraumatic splenic rupture as a cause for unexplained abdominal pain in a patient with a haematological malignancy. |
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