云浮市2001～2005年健康人群乙肝病毒感染分析

目的了解云浮市健康人群乙肝病毒（HBV）感染率及免疫水平，探讨健康人群乙型肝炎防控对策和措施。方法采集43890人健康人群血清，采用酶联免疫吸附法（ELISA）测定HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc5项标志物（HBVM），并按年龄、性别分组进行分析比较。结果HBsAg总阳性率为16．9l％，其中男性为17．80％，女性为16．20％，差异有显著性（P〈0．01）；HBeAg总阳性率为6．46％，其中男性为6．60％，女性为6．34％，差异无显著性（P〉0．05）；抗-HBs总阳性率为43．03％，其中男性为35．73％，女性为48-88％，差异有显著性（P〈0．01）；HBVM全阴率为20．58％，其中男性为26．76％，女性为15．63％，差异有显著性（P〈0．01）；各年龄组间抗-HBs阳性率差异有显著性（P〈0．01）。结论人群中HBV感染率高，易感者多，免疫水平较低，应加强成人乙肝疫苗接种工作，扩大免疫屏障．降低发病率。

Analysis of infectious status of healthy population with HBV in Yunfu City (2002 ～ 2005)

Objective To understand the hepatitis B infection rate and immunization level in healthy population in Yunfu City and discuss the measures for prevention and control of hepatitis B infection in healthy population.Methods Blood serum sample was collected from 43 890 healthy peoples and grouped according to age and gender.Enzyme-linked immuosorbent essay(ELISA)was used for detection of makers of HBsAg,Anti-HBs,HBeAg,Anti-HBe,Anti-HBc.The results were analyzed.Results The total positive rate of HBsAg was16.91%,being 17.80% in the males and 16.20% in the females,showing significant difference(P<0.01);the total positive rate of HBeAg was 6.46%,being 6.60% in the males and 6.34%in the females,without showing significant difference(P<0.05);the total positive rate of anti-HBs was 43.03%,being 35.73% in the males and 48.88% in the females,showing significant difference(P<0.01);The all negative rate of HBV marker was 20.58,being 26.76% in the males and 15.63% in the females,showing significant difference(P<0.01);there significant differences in the positive rate of anti-HBs among each age groups were observed(P<0.01).Conclusion The hepatitis B infection rate is high among ordinary population and the immunization level is low.Therefore,the work of immunization with hepatitis B vaccine in the adults be strengthened to reduce the infection rate.