表皮生长因子受体、p53、Ki-67在三阴性乳腺癌中的表达及其意义

目的 探讨表皮生长因子受体（EGFR）、p53、Ki-67在三阴性乳腺癌（TNBC）中的表达及其意义.方法 回顾性分析53例TNBC和128例非三阴性乳腺癌（NTNBC）临床病理特征,并应用免疫组织化学方法检测EGFR、p53、Ki-67在两者之间的表达差异.结果 TNBC与NTNBC淋巴结转移发生率差异无统计学意义56.6％（30/53）比43.0％（55/128）,P＞0.05],组织学Ⅰ级9.4％（5/53）与32.8％（42/128）]、Ⅲ级50.9％（27/53）与22.7％（29/128）]所占比例差异有统计学意义（P＜0.05）；TNBC中浸润性小叶癌较少5.7％（3/53）],髓样癌较多15.1％（8/53）],与NTNBC 19.5％（25/128）、3.1％（4/128）]相比差异有统计学意义（P＜0.05）；EGFR、p53、Ki-67在TNBC与NTNBC中的表达率分别为62.3％（33/53）与25.0％（32/128）、71.7％（38/53）与47.7％（61/128）、84.9％（45/53）与70.3％（90/128）,差异均有统计学意义（均P＜ 0.05）.结论 TNBC有其独特的临床病理特征,EGFR、p53、Ki-67在TNBC中高表达,提示其恶性程度高,侵袭性强,预后差,EGFR、p53、Ki-67表达可以作为评估TNBC预后的重要参考因素.

Expression of endothelial growth factor receptor, p53, Ki-67 in human triple negative breast carcinoma and their significances

Objective To investigate the expression and significance of endothelial growth factor receptor （EGFR）,p53,Ki-67 in human triple negative breast carcinoma （TNBC）.Methods The clinicopathologic features of 53 cases of human TNBC and 128 cases of non TNBC （NTNBC） were analysed comparatively,and the expression of EGFR,p53,Ki-67 in the two groups were examined using immunohistochemical method.Results There was no significant difference of lymph node metastasis between TNBC and NTNBC in 56.6 % （30/53） vs 43.0 % （55/128）,P 〉 0.05],but their was the significant difference in histological grade Ⅰ 9.4 % （5/53）,32.8 % （42/128）] and grade Ⅲ 50.9 % （27/53）,22.7 % （29/128）]（P 〈 0.05）.In the group of TNBC the rate of invasive lobular carcinoma 5.7 % （3/53）] and medullary carcinoma 15.1% （8/53）] were obviously different from the group of NTNBC 19.5 % （25/128）,3.1% （4/128）]（P 〈 0.05）.The positive rates of EGFR,p53 and Ki-67 were 62.3 % （33/53）,25.0 % （32/128）,71.7 %（38/53） and 47.7 % （61/128）,84.9 % （45/53）,70.3 % （90/128） in the TNBC and NTNBC respectively,and significant differences were found between two groups （P 〈 0.05）.Conclusion The higher expression of EGFR,p53,Ki-67 in TNBC is associated with the high grade with a poor prognosis,therefore,EGFR,p53,Ki-67 could be molecular markers and targets valuable for human breast cancer specially human TNBC.