Cytoprotective and Anti‐secretory Effects of Azadiradione Isolated from the Seeds of Azadirachta indica (neem) on Gastric Ulcers in Rat Models |
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| Authors: | Rohit Singh Vaibhav Mishra Sukanya Pandeti Gautam Palit Manoj K. Barthwal Haushila Prasad Pandey Tadigoppula Narender |
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| Affiliation: | 1. Medicinal and Process Chemistry Division, CSIR‐Central Drug Research Institute, Lucknow, Uttar Pradesh, India;2. Division of Pharmacology, CSIR‐Central Drug Research Institute, Lucknow, Uttar Pradesh, India;3. Department of Biochemistry, Banaras Hindu University, Varanasi, Uttar Pradesh, India |
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| Abstract: | Azadirachta indica is well known medicinal plant mentioned in ancient herbal texts. It has been extensively used in Ayurvedic, Unani and Homoeopathic medicine and has become a luminary of modern medicine. As part of our drug discovery program we isolated azadiradione from the ethanolic extract of seeds of A. indica and evaluated for in‐vivo antiulcer activity in cold restraint induced gastric ulcer model, aspirin induced gastric ulcer model, alcohol induced gastric ulcers model and pyloric ligation induced ulcer model. Azadiradione exhibited potent antiulcer activity through the inhibition of H+ K+‐ATPase (proton pump) activity via its cytoprotective effect and also via its antisecretory effect. This combined effect has valuable potential in the future treatment of peptic ulceration. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | Azadirachta indica azadiradione gastric ulcer proton pump PGE2 |
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