维甲酸在^131I治疗分化型甲状腺癌中的应用

分化型甲状腺癌（DTC）细胞在进展过程中可发生失分化，以致于术后^131I治疗或甲状腺素替代疗效差或无效，成为目前DTC治疗的难题之一。维甲酸作为维生素A的生物活性代谢产物，在调控细胞生长、分化、凋亡等生命活动中起着重要的作用。研究表明，维甲酸能够诱导失分化的DTC细胞再分化，提高肿瘤组织对^131I的摄取能力，从而提高DTC治疗的疗效。

The application of retinoic acids in the ^131I treatment with differentiated thyroid carcinoma

Differentiated thyroid carcinoma（DTC） can occur dedifferentiation in the progress of the process, which results in poor or no effect of the radioiodine therapy and the thyroid hormone replacement therapy after operation. It became one of the most thorny problem for the treatement of DTC now. Retinoic acids, the biologicallyactive metabolite of vitamin A, is of central importance for growth, differentiation, apoptosis and others vital movement of cells. It is demonstrated by studies that retinoic acids-induced redifferentiaon could raise the competence of tumor ingest ^131I, accordingly raise effect of the DTC treatment.