维甲酸在^131I治疗分化型甲状腺癌中的应用 |
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引用本文: | 李艳玲,栾兆生. 维甲酸在^131I治疗分化型甲状腺癌中的应用[J]. 国外医学(放射医学核医学分册), 2009, 0(4): 226-228 |
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作者姓名: | 李艳玲 栾兆生 |
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作者单位: | 解放军第八十八医院核医学科,泰安271000 |
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摘 要: | 分化型甲状腺癌(DTC)细胞在进展过程中可发生失分化,以致于术后^131I治疗或甲状腺素替代疗效差或无效,成为目前DTC治疗的难题之一。维甲酸作为维生素A的生物活性代谢产物,在调控细胞生长、分化、凋亡等生命活动中起着重要的作用。研究表明,维甲酸能够诱导失分化的DTC细胞再分化,提高肿瘤组织对^131I的摄取能力,从而提高DTC治疗的疗效。
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关 键 词: | 维甲酸 甲状腺肿瘤 碘放射性同位素 近距离放射疗法 |
The application of retinoic acids in the ^131I treatment with differentiated thyroid carcinoma |
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Affiliation: | LI Yan-ling, LUA N Zhao-sheng ( Department of Nuclear Medicine, Chinese PLA 88 Hospital, Shandong Taian 271000, China ) |
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Abstract: | Differentiated thyroid carcinoma(DTC) can occur dedifferentiation in the progress of the process, which results in poor or no effect of the radioiodine therapy and the thyroid hormone replacement therapy after operation. It became one of the most thorny problem for the treatement of DTC now. Retinoic acids, the biologicallyactive metabolite of vitamin A, is of central importance for growth, differentiation, apoptosis and others vital movement of cells. It is demonstrated by studies that retinoic acids-induced redifferentiaon could raise the competence of tumor ingest ^131I, accordingly raise effect of the DTC treatment. |
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Keywords: | Retinoic acids Thyroid neoplasms Iodine radioisotopes Brachytherapy |
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