溶栓治疗对急性心肌梗死患者血浆ET-1、hs-CRP、TXA2、NO水平的影响

目的探讨溶栓治疗对急性心肌梗死(AMI)患者血浆内皮素(ET-1)、超敏C反应蛋白(hs-CRP)、血栓素A2(TXA2)、一氧化氮(NO)水平的影响及其临床意义。方法病例组32例,采用尿激酶溶栓治疗,分别测出溶栓前后再通组和未通组ET-1、NO、hs-CRP、TXA2水平的动态变化。正常对照组测空腹ET-1、NO、hs-CRP、TXA2水平。结果病例组ET-1、hs-CRP、TXA2水平高于正常对照组(P<0.05),NO水平低于正常对照组(P<0.05);溶栓再通组的ET-1、NO、hs-CRP、TXA2水平显著增高,且峰值显著高于溶栓未通组的峰值(P<0.05);再通组ET-1、hs-CRP、TXA2和NO峰值提前,都在溶栓后3 h,而溶栓未通组峰值均为溶栓后5h。结论 ET-1、hs-CRP、TXA2和NO相互作用,参与了AMI的循环炎症反应和再灌注损伤,可作为判断AMI病情及溶栓治疗再通的可能指标。

Effect of Thrombolytic Therapy on Plasma Endothelin,hs-CRP,TXA2,and NO in Acute Myocardial Infarction

Objective To study the effect of thrombolytic therapy patients on plasma endothelin-1(ET-1),high sensitive C-reactive protein(hs-CRP),thromboxane A2(TXA2),nitric oxide(NO) levels in patients(pts) acute myocardial infarction(AMI).Methods Thirty-two pts with AMI were treated with urokinase,and then divided into recanalization group and non-recanalization group.The levels of plasma ET-1,NO,hs-CRP,TXA2 were measured.Results The levels of plasma ET-1,hs-CRP,TXA2 in treatment group were higher(P<0.05),and NO leve...