Identification and quantitation of JWH-213, a cannabimimetic indole, as a designer drug in a herbal product |
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Authors: | Kazunaga Takahashi Nahoko Uchiyama Tomohide Fukiwake Takashi Hasegawa Masaaki Saijou Yuji Motoki Ruri Kikura-Hanajiri Yukihiro Goda |
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Institution: | 1. Chiba Prefectural Institute of Public Health, 666-2 Nitona-cho, Chiba, Chiba, 260-8715, Japan 2. National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan
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Abstract: | In our survey of designer drugs in the Japanese market, a cannabimimetic indole was identified as a new active compound in a herbal product. The structure of this compound was elucidated by liquid chromatography–photodiode array–mass spectrometry (LC–PDA–MS), gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance (NMR) analyses. The compound was finally identified as (4-ethyl-1-naphthalenyl)(2-methyl-1-pentyl-1H-indol-3-yl)methanone (JWH-213), an indole-based cannabinoid receptor ligand. To our knowledge, this is the first finding of JWH-213 as a designer drug in a herbal product. The quantitative LC–PDA analysis showed that the JWH-213 content in the product was 252 mg/pack. |
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