消栓通络方有效成分组对大鼠急性血瘀模型的影响

在"中药复方有效成分组"理论指导下,观察消栓通络方有效成分组(the effective components group of Xiaoshuantongluo formula,XECG)对大鼠急性血瘀模型的影响。采用皮下注射肾上腺素加冰水浴制备大鼠急性血瘀模型,评价XECG对全血黏度、血浆黏度、红细胞聚集率、血小板聚集率等血液流变学指标,PT、APTT、TT和FIB等凝血指标以及体内6-keto-PGF1α、TXB2和D-dimer水平的影响。结果表明,XECG显著降低ADP诱导的血小板聚集,但对全血黏度、血浆黏度、红细胞聚集率无明显影响;能延长PT和TT,对APTT和FIB含量无影响;可显著降低急性血瘀大鼠血浆中D-dimer水平,轻微降低TXB2的含量,但对6-keto-PGF1α的含量无影响。结果提示,XECG的作用在抗血小板聚集方面表现得更为突出和专一。

Effects of the effective components group of xiaoshuantongluo formula on rat acute blood stasis model

Effects of the effective components group of Xiaoshuantongluo formula (XECG) on rat acute blood stasis model were studied under the guidance of the concept of effective components group. Rat acute blood stasis model was induced by subcutaneous injection of epinephrine combined with ice water bath. Hemorheology indices such as whole blood viscosity, plasma viscosity, erythrocyte aggregation index and platelet aggregation rate; coagulation parameters including PT, APTT, TT and FIB; 6-keto-PGF1alpha, TXB2 and D-dimer levels were determined to evaluate the effects of XECG. The results showed that XECG significantly reduced ADP-induced platelet aggregation, but showed little influence on the whole blood viscosity, plasma viscosity and erythrocyte aggregation rate. XECG extended PT and TT slightly, but had no effects on APTT and FIB content. D-dimer levels significantly decreased after administration of XECG with a little decrease of TXB2, but the content of 6-keto-PGF1alpha did not change significantly. The results suggest that the role of XECG of anti-aggregation is more prominent.