| 麋鹿角醇提液对衰老小鼠行为及免疫功能的影响 |
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| 引用本文： | 杨朝晔,秦红兵,成海龙,朱清.麋鹿角醇提液对衰老小鼠行为及免疫功能的影响[J].中华中医药杂志,2010(2). |
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| 作者姓名： | 杨朝晔 秦红兵 成海龙 朱清 |
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| 作者单位： | 江苏省盐城卫生职业技术学院免疫学教研室;江苏省盐城卫生职业技术学院药理学教研室;江苏省南通大学医学院药理学教研室; |
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| 基金项目： | 江苏省卫生厅资助项目(No.J200504)~~ |
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| 摘 要： | 目的:观察麋鹿角醇提液对衰老小鼠行为以及免疫功能的影响。方法:取ICR小鼠54只,雌雄兼用,随机分成4组:正常对照组(NG),模型对照组(MG),低剂量给药组(LG,2g.kg-1.d-1),高剂量给药组(HG,4g.kg-1.d-1)。用D-半乳糖(D-gal)按120mg.kg-1.d-1背部皮下注射,造成亚急性衰老模型。造模同时,低剂量组和高剂量组分别给予相应浓度的麋鹿角醇提液。6周后,对各组小鼠行Y-迷宫行为学测试;采用单向琼脂扩散法,测定各组小鼠血清IgG水平;使用MTT比色法测定小鼠脾淋巴细胞转化刺激指数;ELISA法检测血清中细胞因子IL-2,IFN-γ的浓度。结果:衰老小鼠记忆功能和免疫功能明显下降,麋鹿角醇提液能显著提高衰老小鼠记忆功能,增加IgG水平;增加脾淋巴细胞转化刺激指数;升高血清中IL-2和IFN-γ的浓度。结论:麋鹿角醇提液可以改善衰老小鼠的行为学表现,增强其免疫功能以延缓衰老进程。
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| 关 键 词： | 麋鹿角 衰老 D-半乳糖 行为 免疫功能 |
Effects of elk antlers ethanolic fluidextract on behavior and immune function of aging model mice |
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| YANG Zhao-ye,QIN Hong-bing ,CHENG Hai-long,ZHU Qing.Effects of elk antlers ethanolic fluidextract on behavior and immune function of aging model mice[J].China Journal of Traditional Chinese Medicine and Pharmacy,2010(2). |
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| Authors: | YANG Zhao-ye QIN Hong-bing CHENG Hai-long ZHU Qing |
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| Institution: | 1Department of Immunology;Yancheng Health Vocational and Technical College;Yancheng 224006;China;2Department of Pharmacology;3Department of Pharmacology;Medical College of Nantong University;Nantong 226001;China |
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| Abstract: | Objective: To observe the effect of elk antlers ethanolic fluidextract on behavior and immune function of aging model mice. Methods: ICR mice were randomly divided into 4 groups: Normal control group (NG), model control group (MG), low-dose drug treatment group (LG,2g/kg) and high-dose drug treatment group (HG,4g/kg). Mice were given subcutaneous injection of D-galactose (D-gal) at 120 mg/kg to induce subacute aging model. At the same time LG and HG were respectively administrated corresponding concentratio... |
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| Keywords: | Elk antlers Aging D-galactose Behavior Immune function |
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