| 枳实中黄酮成分及其提取物大鼠肠吸收特性研究 |
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| 引用本文： | 辛然,陈彦,贾晓斌,谭晓斌,王晋艳.枳实中黄酮成分及其提取物大鼠肠吸收特性研究[J].中国中药杂志,2010,35(14):1850-1854. |
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| 作者姓名： | 辛然 陈彦 贾晓斌 谭晓斌 王晋艳 |
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| 作者单位： | 1. 江苏省中医药研究院,中药新型给药系统重点实验室,国家中医药管理局中药口服制剂释药系统重点研究室,江苏,南京,210028;江苏大学药学院,江苏,镇江,212013
2. 江苏省中医药研究院,中药新型给药系统重点实验室,国家中医药管理局中药口服制剂释药系统重点研究室,江苏,南京,210028 |
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| 基金项目： | 国家中医药管理局中医药科学技术研究专项(06-07ZP18);江苏省中医药领军人才项目(2009) |
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| 摘 要： | 目的:考察枳实中3种活性黄酮成分柚皮苷、橙皮苷、新橙皮苷及枳实提取物在大鼠肠道的吸收特性。方法:采用大鼠肠灌流模型和肠道酶共孵育实验研究各成分及提取物在大鼠肠道的吸收代谢特性,同时测定各成分的表观油水分配系数。结果:柚皮苷、橙皮苷、新橙皮苷及枳实提取物在大鼠肠道的有效渗透系数Peff值均较小,柚皮苷在0.140～0.252,橙皮苷在0.156～0.268,新橙皮苷在0.154～0.285,化合物在不同肠段中的Peff值无显著差异,不同浓度间的Peff值也无显著差异;相同浓度下,枳实提取物中各成分的Peff值高于相应单一成分。各成分与肠道酶共孵育均未检测到代谢物。测得柚皮苷、橙皮苷、新橙皮苷的表观油水分配系数P分别为0.36,0.40,0.48,且pH对其影响不大。结论:柚皮苷、橙皮苷、新橙皮苷在大鼠肠道的渗透性较差是其吸收差的一个重要原因;枳实提取物中各成分较相应单一成分在大鼠肠道的吸收有提高,表明可能存在成分间的相互作用促进其吸收。
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| 关 键 词： | 枳实 黄酮成分 提取物 吸收 大鼠肠灌流 肠道酶 表观油水分配系数 |
| 收稿时间： | 2009/10/14 0:00:00 |
Intestinal absorption properties of flavones and extract of Fructus Aurantii Immaturus in rats |
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| XIN Ran,CHEN Yan,JIA Xiaobin,TAN Xiaobin and WANG Jinyan.Intestinal absorption properties of flavones and extract of Fructus Aurantii Immaturus in rats[J].China Journal of Chinese Materia Medica,2010,35(14):1850-1854. |
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| Authors: | XIN Ran CHEN Yan JIA Xiaobin TAN Xiaobin and WANG Jinyan |
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| Institution: | Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Key Laboratory of Multi-delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Key Laboratory of Multi-delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Key Laboratory of Multi-delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Key Laboratory of Multi-delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Key Laboratory of Multi-delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China |
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| Abstract: | |
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| Keywords: | Fructus Aurantii Immaturus flavonoids extract absorption rat intestinal perfusion intestinal enzymes apparent oil/water partition coefficient |
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