| 乳腺肿瘤中nm23-H1、MTA1蛋白表达与癌浸润转移的关系 |
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| 引用本文： | 申培红,王旭东,马梅,马杰.乳腺肿瘤中nm23-H1、MTA1蛋白表达与癌浸润转移的关系[J].医药论坛杂志,2009(10). |
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| 作者姓名： | 申培红 王旭东 马梅 马杰 |
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| 作者单位： | 郑州大学第五附属医院病理科;河南省肿瘤医院病理科; |
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| 摘 要： | 目的探讨nm23-H1、MTA1蛋白在乳腺肿瘤中的表达情况,研究其在乳腺癌发生、发展中的生物学意义并观察其与乳腺癌浸润及转移的内在关系。方法采用免疫组化SP法检测50例乳腺肿瘤组织中nm23-H1和MTA1蛋白的表达情况。结果乳腺浸润性导管癌组织nm23-H1蛋白阳性表达率明显低于乳腺纤维腺瘤(P<0.05);乳腺浸润性导管癌组织MTA1蛋白阳性表达率明显高于乳腺纤维腺瘤(P<0.05);乳腺肿瘤中nm23-H1和MTA1蛋白表达呈负相关(P<0.05)。结论MTA1蛋白高表达及nm23-H1蛋白低表达与乳腺癌发生浸润转移有关,二者在乳腺癌发生浸润转移过程中可能起着正负调控作用。联合检测此指标的表达状况将有助于乳腺癌的早期诊断和预后判断。
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| 关 键 词： | 乳腺癌 浸润和转移 nm23-H1 MTA1 免疫组化 |
Expression of MTA1 and nm23-H1 Protein and Its Relationship with Metastasis of Breast Neoplasm |
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| SHEN Peihong,WANG Xudong,MA Mei,et al.Expression of MTA1 and nm23-H1 Protein and Its Relationship with Metastasis of Breast Neoplasm[J].Journal of Medical Forum,2009(10). |
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| Authors: | SHEN Peihong WANG Xudong MA Mei |
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| Institution: | SHEN Peihong,WANG Xudong,MA Mei,et al Department of Pathology,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To explore the expression of MTA1 and nm23-H1 protein and its relationship with invasive and metastasis of breast neoplasm.Methods Immunohistochemistry technique SP method was used to detect the expression of MTA1 and nm23-H1 protein in 50 cases of breast neoplasm.Results The positive expressions rates of MTA1 protein with the presence in the invasive ductal carcinoma of the breast were higher than that in the fibroadenoma(P <0.05);The positive expressions rates of nm23-H1 protein with the presenc... |
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| Keywords: | Breast neoplasm Invasive and metastasis MTA1 nm23-H1 Immunohistochemistry |
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