灯盏花注射液对小鼠肝损伤生化指标的影响

目的：观察灯盏花注射液对小鼠肠缺血再灌注肝损伤生化指标的影响。方法：制作小鼠肠缺血再灌注肝损伤模型。小鼠缺血时间20min，再灌流1h后制备血清；摘取肝脏，制备肝匀浆，测定肝脏超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量。结果：小鼠血清ALT明显增高，灯盏花注射液能降低缺血再灌注肝损伤小鼠血清ALT的活性（P＜0．01）；还可使SOD活性和MDA含量明显恢复（P＜0．05或P＜0．01）。结论：灯盏花注射液可改善小鼠肠缺血再灌注肝损伤时生化指标，提示灯盏花注射液对小鼠肠缺血再灌注肝损伤有保护作用，且肝保护作用机制与其抗氧化作用有关。

Effect of Erigeron Injection on Biochemical Indicators of Hepatotoxicity in Mice

Objective: To observe the effects of erigeron injection on the biochemical indicators of hepatotoxicity caused by ischemia and reperfusion of the mice intestine. Methods:A experimental model of liver lesion induced by ischemia-reperfusion of the mice intestine was set up. Serum was obtained after 20 minutes of ischemia followed by 1 hour of reperfusion. Contents of SOD and MDA in liver were measured. Results: The serum ALT significantly increased following ischemia and reperfusion, which was attenuated by the erigeron injection (P<0.01). Erigeron injection can also increase the contents of SOD and MDA in the mice liver (p<0.05 and 0.01, respectively). Conclusion: Erigeron injection can improve the biochemical indicators of liver lesion induced by ischemia and reperfusion of the mice intestine. It is indicated that the protective effects of erigeron injection was related to anti-oxidation mechanisms.