帕罗西汀与阿米替林治疗首发抑郁症认知功能损害的疗效比较

目的比较盐酸帕罗西汀与阿米替林对首发抑郁症患者认知功能损害的疗效。方法 120例首发抑郁患者接受12周帕罗西汀（A组,n=60）或阿米替林（B组,n=60）治疗。治疗前和治疗8周末采用17项汉密顿抑郁量表（HAMD）和汉密顿焦虑量表（HAMA）评定疾病严重程度,用威斯康星卡片分类测验（WCST）评定患者认知功能。结果经两样本t检验,治疗前A组比B组的WCST总数和持续错误数无统计学意义（P〉0.05）。比起B组,治疗后A组的正确数、分类数增多,WCST总数和持续错误数明显减少（P〈0.05）。经配对t检验,治疗后A组和B组的WCST总数和持续错误数比治疗前明显减少（P〈0.05或P〈0.01）,A组的WCST总数和持续错误数明显减少（P〈0.05）。结论帕罗西汀与阿米替林治疗首发抑郁症均能改善患者的认知功能,帕罗西汀缓解重度抑郁症患者的临床症状、改善患者认知功能比阿米替林明显。

The cognition function comparison study between Paroxetine and Amitriptyline hydrochloride in first-episode major depression treatment

Objective To compare the cognition function of the first episode major depressed patients after paroxetine and amitriptyline（AMT） hydrochloride treatment.Mehtods 120 patients were parallel assigned to two groups receiving paroxetine（group A,n=60） and amitriptyline（AMT） hydrochloride（group B,n=60） antidepressant 12 weeks respectively.Using Hamilton Depression Scale（17 item） and Hamilton Anxiety Scale to evaluate severity,and using WCST neuropsychological tests twice before and after treatment to evaluate cognition function of the two groups patients.Results The patients display similarly on WCST neuropsychological tests（P0.01） before treatment.The group A did better on WCST than the group B（P0.01） after treatment.The patients had improvement in WCST tests scores after treatment（P0.05）.Compared with group B,group A patients had obviously did better on the WCST tests.Conclusion Paroxetine and amitriptyline（AMT） hydrochloride can improve cognition function of first episode depressive patient,paroxetine has superiority to alleviate severe depressive patient symptoms,improve performance in cognitivel tests than amitriptyline（AMT） hydrochloride does.