| 枸杞总黄酮类化合物抗脂质过氧化研究 |
| |
| 引用本文： | 黄元庆,鲁建华,沈泳. 枸杞总黄酮类化合物抗脂质过氧化研究[J]. 卫生研究, 1999, 28(2): 115 |
| |
| 作者姓名： | 黄元庆 鲁建华 沈泳 |
| |
| 作者单位： | 宁夏医学院营养与食品卫生教研室，兰州医学院第二附属医院眼科，北京医科大学天然与仿生药物国家重点实验室 |
| |
| 摘 要： | 利用Ｆｅ２＋－Ｃｙｓ－Ｈｉｓ体系诱发鼠肝线粒体和红细胞产生脂质过氧化的方法，研究了枸杞总黄酮类化合物（ＴＦＬ）的抗脂质过氧化作用。结果表明，ＴＦＬ可阻断该体系诱发的鼠肝线粒体脂质过氧化，当ＴＦＬ终浓度在０．０２５～２．０ｍｇ／ｍｌ范围时，对丙二醛（ＭＤＡ）生成阻断率为３８．３８％～９９．９６％，呈剂量－效应关系，同时具有保持线粒体膜流动性的作用。扫描电镜观察到ＴＦＬ对脂质过氧化所致红细胞形态结构的破坏有保护作用。
|
| 关 键 词： | 枸杞总黄酮 线粒体 脂质过氧化 |
The protective effects of total flavonoids from Lycium Barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats |
| |
| Huang Yuanqing,Lu Jianhua,Shen Yong,Lu Jingfen,et al.. The protective effects of total flavonoids from Lycium Barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats[J]. Journal of hygiene research, 1999, 28(2): 115 |
| |
| Authors: | Huang Yuanqing Lu Jianhua Shen Yong Lu Jingfen et al. |
| |
| Affiliation: | Huang Yuanqing,Lu Jianhua,Shen Yong,Lu Jingfen,et al. Department of Nutrition and Food Hygiene,Faculty of Preventive medicine,Ningxia Medical College,Yinchuan 750004,China |
| |
| Abstract: | The protective effects of total flavonoids from Lycium Barbarum L.(TFL) on lipid peroxidation in mitochondria and red blood cells (RBC) induced by oxygen radicals produced by Fe 2 cysteine system were investigated. The mitochondria lipid peroxidation (measured as malondialdehyde, MDA) was significantly inhibited by TFL with a dose response relation between the concentrations of 0 025 and 2 0 mg/ml, and the fluidity of mitochondria membrane was also protected effectively. It was observed by scan electron microscope, that the shape of RBC in the Fe 2 system was damaged significantly. The shape of RBC was remained with the addition of TFL. |
| |
| Keywords: | flavonoids of Lycium Barbarum L. lipid peroxidation mitochondria |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
