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GC-MS assay for acetaminophen in human hair segments |
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| Authors: | Takeshi Saito Seiji Morita Shigeaki Inoue Isotoshi Yamamoto Sadaki Inokuchi |
| Affiliation: | (1) Emergency and Critical Care Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan |
| Abstract: | A detailed procedure for sensitive analysis of acetaminophen (APAP) in human hair segments by gas chromatography-mass spectrometry is reported. The limit of quantitation was as low as 0.1 ng/mg. The linear concentration range of the assay was 0.1–10 ng/mg. The interday and intraday coefficients of variation were below 10%. The method was successfully applied to hair analysis of APAP in an actual poisoning case. |
| Keywords: | Acetaminophen Hair analysis GC-MS Segmental analysis Solid-phase extraction Alternative specimen |
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