| 1．5Gy X射线全身照射对小鼠胸腺细胞CD_3、CD_4、CD_8分子表达及 |
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| 引用本文： | 鞠桂芝,苏旭,齐进,张迎春,刘建相,刘树铮.1．5Gy X射线全身照射对小鼠胸腺细胞CD_3、CD_4、CD_8分子表达及[J].中华放射医学与防护杂志,1995(2). |
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| 作者姓名： | 鞠桂芝 苏旭 齐进 张迎春 刘建相 刘树铮 |
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| 作者单位： | 白求恩医科大学卫生部放射生物重点实验室 |
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| 摘 要： | 采用单克隆抗体免疫荧光技术，流式细胞术检测，观察了１．５ＧｙＸ射线单次全身照射（剂量率０．２８６Ｇｙ／ｍｉｎ）对小鼠胸腺细胞ＣＤ３分子表达的影响，及胸腺细胞亚群和细胞周期的变化。结果表明，中等剂量照射后，胸腺细胞ＣＤ３分子的百分率明显增高，胸腺细胞ＣＤ３阳性细胞比例为对照组的１７７．６１％。同时，胸腺中ＣＤ４＋及ＣＤ８＋细胞比例亦显著增加，分别为对照的２０２．５％及１６５．８７％。然而，胸腺中ＣＤ４＋、ＣＤ８＋细胞的比例显著降低，为对照组的６８．２８％，与此同时，胸腺细胞周期中Ｓ期细胞比例明显降低，为对照组的５５．１４％。
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| 关 键 词： | 亚致死剂量，胸腺细胞，CD_3分子表达，CD_4~＋，CD_8~＋ |
Effect of 1.5 Gy whole body irradiation with X-rays on expression of CD_3molecules in thymus of mice. |
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| Ju Guizhi,Qi Jin,Su Xu,ef al..Effect of 1.5 Gy whole body irradiation with X-rays on expression of CD_3molecules in thymus of mice.[J].Chinese Journal of Radiological Medicine and Protection,1995(2). |
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| Authors: | Ju Guizhi Qi Jin Su Xu ef al |
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| Abstract: | The effect of whole body irradiation on CD3 expression of thymocytes was investigated in Kunming mice which were irradiated with 15 Gy X-rays at the dose rate of 0.286 Gy/min.At 18h after irradiation the mice were sacrificed and the changes of CD0 ,CD4 ,CD8 cells were measured by flow cytometry with immunofluorescence.The results showed that the CD8cells in the irradiated group increased 177.61 percent over the control group because of the increase of CD4 CD8- and CD4-CD8 cells with CD3 complex while the CD4 CD8 cells markedly decreased following irradiation. |
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| Keywords: | Whole body irradiation CD_3 expression thymocytes |
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