| 住院特殊人群和需进行治疗药物监测的药品不良反应报告分析 |
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| 引用本文： | 徐丽. 住院特殊人群和需进行治疗药物监测的药品不良反应报告分析[J]. 中国执业药师, 2012, 9(8): 7-9,13 |
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| 作者姓名： | 徐丽 |
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| 作者单位： | 日照市人民医院,山东日照,276826 |
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| 摘 要： | 目的:了解我院住院特殊人群和需进行治疗药物监测(TDM)的药品不良反应(ADR)分布,促进临床合理用药。方法:对我院2005-2011年临床各科室呈报的ADR病例,按照国家ADR监测中心制定的标准进行描述、因果关系分析评价、分级汇总及统计分析。结果:2159例ADR报告中男性1146例(53.07%),女性1013例(46.93%);在需进行TDM的药物中,引起ADR比率最高的为抗癫痫类药物(60.77%);ADR病例数随着肝功能和肾功能损害的加重而增加。结论:我院住院特殊人群和需进行TDM的药物的ADR较多,应合理使用药物,并对ADR予以关注。
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| 关 键 词： | 特殊人群 治疗药物监测 药品不良反应 |
The Analysis of Adverse Drug Reactions Reports in Special Inpatients and the Drugs under Therapeutic Drug Monitoring |
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| Xu Li. The Analysis of Adverse Drug Reactions Reports in Special Inpatients and the Drugs under Therapeutic Drug Monitoring[J]. China Licensed Pharmasist, 2012, 9(8): 7-9,13 |
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| Authors: | Xu Li |
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| Affiliation: | Xu Li (The People＇s Hospital of Rizhao City, Shandong Rizhao 276826, China) |
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| Abstract: | Objective： To analyze the characteristics of the adverse durg reactions （ADRs） in the special groups of inpatients and the drugs under therapeutic drug monitoring （TDM） in our hospital so as to promote clinical rational drug use. Methods： The ADR case reports submitted by our hospital during 2005 - 2011 and their causal relationship were evaluated, graded and statistically analyzed in accordance with the standards set by the State ADR Monitoring Center. Results： Of 2 159 submitted cases 1 146 were male （ 53.07 % ） and 1 013 female （46.93 % ）. Antiepileptic drugs showed the highest ADR ratio（60.77%） among the drugs under TDM. There was an increase of ADR cases with the aggravation of liver and renal impairment. Conclusion： Great attention should be paid to rational use of drugs so as to reduce ADRs in special groups of inpatients and drugs under TDM. |
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| Keywords: | Special Population Therapeutic Drug Monitoring Adverse Drug Reaction |
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